Interventions for proliferative diabetic retinopathy show lower risk of anxiety and depression

New research suggests that surgical and non-surgical interventions for proliferative diabetic retinopathy (PDR) reduced the risks of comorbid anxiety and depression.

However, the study data shows that repairing retinal detachment was only associated with higher risks of anxiety, not depression.

“These findings underscore the importance of multidisciplinary care in the management of patients with diabetic retinal detachments,” wrote study author Vikram Ponnusamy, MD, University of North Carolina System.

These findings were presented at the Association for Research in Vision and Ophthalmology (ARVO) 2022 meeting in Denver, Colorado.

As the leading cause of preventable blindness in working-age adults, vision loss due to diabetic retinopathy has a significant effect on social, economic and emotional well-being. Major depressive disorder and general anxiety disorder are common in people with diabetes, especially in patients with PDR.

The retrospective case-control study quantified the association between different interventions for the treatment of PDR, and anxiety and depression. Patients over the age of 18 were identified with a diagnosis of PDR between January 2014 and December 2020 via ICD-9 and ICD-10 codes.

Additionally, comorbid anxiety and depression were determined via ICD-9 and ICD-10 diagnostic codes.

Additionally, CPT codes identified patients diagnosed with PDR who received treatment as follows:

  • Intravitreal injection
  • Panretinal photocoagulation (PRP)
  • Pars plana vitrectomy (PPV)
  • PPV with endolaser
  • Repair of retinal detachment (RDR)
  • Complex RDR
  • Removal of silicone oil

The investigators used several logistic regression models to obtain an estimated odds ratio (OR) and confidence intervals while stratifying and adjusting for sex and age.

Of a total of 3572 patients with PDR, 648 suffered from anxiety and 979 suffered from depression. Patients who received an intravitreal injection had a lower risk of comorbid anxiety compared to untreated PDR patients (OR, 0.835, 0.738, 0.944; P <.001>

Additionally, the researchers found a reduced risk of comorbid depression when comparing patients who received intravitreal injections (OR, 0.584, 0.525-0.650; P <.001 ppv with endolaser>P P <.001 to patients who did not have an intervention for pdr.>

Additionally, RDR (OR, 1.759, 1.044 – 2.966; P <.001 and complex rdr>P

“These results shed further light on the relationship between mental health and diabetic retinopathy,” Ponnusamy concluded.

The study, “Anxiety and Depression in Patients Treated for Proliferative Diabetic Retinopathy,” was presented at ARVO 2022.

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