Treatment Of Depression – Tenil Mon, 04 Jul 2022 16:00:00 +0000 en-US hourly 1 Treatment Of Depression – Tenil 32 32 Ruby Wax credits new treatment for lifting her out of depression Mon, 04 Jul 2022 16:00:00 +0000
Ruby Wax credits new <a class=treatment for lifting her out of depression [Instagram] Credit: Bang Showbiz” src=”–/YXBwaWQ9aGlnaGxhbmRlcjt3PTk2MA–/–~B/aD0wO3c9MDthcHBpZD15dGFjaHlvbg–/″/>

Ruby Wax credits new treatment for lifting her out of depression [Instagram] Credit: Bang Showbiz

Ruby Wax has credited a new treatment with helping her recover from a recent bout of depression.

The 69-year-old actress revealed just two weeks ago that she was suffering from her first bout of depression in 12 years, but now believes undergoing repetitive transcranial magnetic stimulation treatment helped her.

She shared a photo of herself on Instagram, wearing a special helmet for the procedure and wrote, “I’m better now, but the quicksand extraction of depression is so slow it’s faster to see your hair grow.

“The last time it happened to me about twelve years ago it took me months to get back to what I was, this time it only took weeks.”

After joking that the procedure saved her from being one of the “walking dead,” Ruby went into detail about what it entails.

She wrote: “I’m better now but the quicksand extraction of depression is so slow it’s faster to see your hair grow. Last time this happened to me was about twelve years ago years, it took months to get back to who I used to be, this time it only took weeks.

“Here’s how I retired from being among the walking dead, there’s a new machine called rTMS (repetitive transcranial magnetic stimulation).

“If you had told me five years ago that something like this existed, I would have thought you had watched too much science fiction. rTMS is different from ECT (for electroconvulsive therapy), which is the latest saloon treatment for those who don’t.With ECT they knock you out, put some between your teeth so you don’t bite your tongue and let the tension tear.

“The electrical currents cause a little seizure that hopefully changes brain chemistry. In other words, you’re fried and even worse, there’s a good chance there’s short-term memory loss. term. Not good for any human being who wants to remember his Name.”

Ruby explained that the procedure is 60% successful and revealed how lucky she feels to be part of that percentage.

She said: “The Repetitive Transcranial Magnetic Stimulator doesn’t use electricity, it uses a magnetic pulse that kicks your neurons into action, like restarting a broken down car. It works on 60% of patients with depression. , OCD and a few other mental disorders and thank you Jesus I was in that 60 percent.

“They put something that looks like a 50s hair dryer on your head and then the banging started.

“Looks like Woody Woodpecker was dropped on the left side of your head and he’s having a hay day. Those magnets hit you about 36 times every few seconds, up to 55 times. That’s about 1,980 strokes to recalibrate your brain (not pleasant).

“I’ve had twenty sessions and a rework of meds and who would have dreamed it, I’m almost human again. I can almost smile, which is an impossibility during the dark nights of mental knives. There’s only There are a handful of places in the UK that offer treatment using this equipment, as mental illness is probably the lowest on the list when it comes to taking illness seriously.

“For me, that’s actually the most serious because a diseased brain is usually the underlying cause of most physical illnesses.

“But we know the stigma blah blah blah… and we don’t do enough of it.

“That’s why with mental illness, forget getting the right help, forget getting the right meds, forget a bed in a hospital, forget seeing a psychiatrist – so really why would they bother putting this magical equipment available to lean 1 of 4?

“I will continue to lead the fight.”

Patients Praise the Value and Benefits of Light Therapy Treatments | News, Sports, Jobs Sat, 02 Jul 2022 22:35:34 +0000

Photo provided

A ReGen pod, used at the wellness center, is shown in this undated photo.

SOUTH OGDEN — Jeff Guthrie was sick, weak, tired and depressed. After being infected with COVID-19, his symptoms persisted. The Eden resident couldn’t even walk 20 feet without having to sit up and catch his breath.

“It’s awful,” Guthrie said. “It left me with lung issues and really bad depression. That’s when Laura called me and told me to come and try a therapy session. I can’t believe how great a difference in my life.

The machine, called ReGen Pod, uses red light and near-infrared laser light therapy to improve overall health, according to the manufacturer’s website.

Laura Warburton is the owner of the Wellness Center, which has a location in Huntsville and a recently opened one in South Ogden. She said the therapy worked so well for her that she wanted to share it with others.

The therapy uses low level wavelengths of red light, which can have a biochemical effect on cells in the body and, in turn, help reduce inflammation and pain in the body. The website says the therapy can even have positive results with anxiety and depression.

“My depression is like night and day,” Guthrie said. “I have more energy. All I can say is that I lay in there for 20 minutes and I feel better.

Warburton’s journey to the wellness center began when she was diagnosed with terminal hydrocephalus, a condition in which fluid builds up in the deep cavities of the brain. The condition was the result of an accident she suffered years ago.

“The main symptoms are dementia, incontinence, uneven walking and extreme fatigue,” she said. “Over the past five years, I’ve learned to accept it and do my best. I had two brain surgeries. I was placed on a shunt which resolved most of my symptoms but still left me feeling tired and foggy most of the time.

Warburton did everything she could think of – she even moved to Mexico for a while to be closer to sea level, but the lack of her family brought her back to Utah.

“Around the same time, an ad on Facebook caught my eye. It was for a concussion support center,” she said. “I wanted to learn more to help others, not necessarily myself.”

Warburton, a resident of Huntsville, said she learned more about the full body modules and did a free session.

“I was blown away,” she said. “I’ve had so much energy – enough to quit the La-Z-Boy and start two businesses. My brain is so much better. I’m also calmer. My arthritis is gone.

According to the Cleveland Clinic, red light therapy continues to grow and shows promise in several areas of medicine, including the treatment of acne, scars, skin cancer and other medical conditions. However, the clinic states that full effectiveness for certain conditions has yet to be determined, and to date, there is no scientific evidence to support weight loss or cellulite removal.

Warburton opened her first business in her home and business boomed, she said. That’s when she decided to open her second location in South Ogden in June.

“We don’t claim to cure anything, and we don’t diagnose,” she said. “Without a doubt, the clove reduces inflammation. Inflammation causes pain. There are other full body pods available, none in Weber County. However, there is only one pod which is programmable and sends frequencies into the body. The ReGen Q8 module. Simply put, everything is energy and when measured it is called frequency.

Warburton added that the process, when pulsing frequencies through the four beneficial light spectra, is similar to acupuncture with light.

“It literally reaches every cell in your body, stimulating them to their highest and best use,” Warburton says.

Jason Smith, a chiropractor with a master’s degree in clinical neuroscience who practices at Bountiful, said he’s been using laser light therapy for more than 15 years. He said light therapy helps speed up cell division so people recover faster.

“There are thousands of research papers on the subject,” he said. “Light therapy can help with everything from post-surgery recovery, wound healing, concussions, and acne. It’s been shown to improve brain function and reduce pain. I’ve used it myself myself and I feel more energetic and creative. It feels like a magic bullet, but it improves the functioning of the body.

The only contradiction to using the capsule, Warburton said, is for people undergoing immunosuppressive therapy for cancer or other illnesses.

“The pods boost your immune system, so we never allow anyone with cancer without written approval from a doctor,” she said. “There are interesting studies for every possible disease on the Google Scholar site. Just search for ‘photobiomodulation’ and insert the disease and a number of peer-reviewed studies are available to read.” also states that, although more studies are needed, red light therapy may help with dental pain, hair loss, dementia, osteoarthritis, and tendonitis.

The pod looks like a tanning bed. Once inside, the machine is programmed to deliver a pulse of light at varying levels, depending on the reason for its use. The maximum time for each session is 15 to 20 minutes. The first session is always free. After that, a discounted six-session package would cost $275. A walk-in session costs $65.

Clinton’s Janice Hill used the capsule to relieve knee pain, headaches, and anxiety.

“I didn’t feel any pain when I got out of the basket the first time. I had relief for a while,” she said. “I’ve been back to it several times and when I’m done the pain is usually gone. It’s very relaxing and definitely has other benefits. I feel more energy and more clarity in my thinking.

Guthrie said he was so pleased with the results that he sent dozens of people to try it out for themselves.

“People asked me if it was snake oil,” he said. “Well, if it’s snake oil, it worked for me.”

The wellness center is located at 1724 Combe Road in South Ogden and also at Warburton’s home in Huntsville. For an appointment, people can call 801-800-2484.


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Axsome’s long-delayed depression drug is back for label talks at the FDA, triggering a sharp rise in stock price – Endpoints News Tue, 28 Jun 2022 18:21:00 +0000

Axsome’s on-and-off quest to gain FDA approval for its depression drug AXS-05 is back on.

After markets closed on Monday, the biotech issued a short, simple alert in an SEC filing stating that the team had “received from the United States Food and Drug Administration (the “FDA”) proposed labeling for the Company’s product candidate AXS-05 with respect to its New Drug Application (the “NDA”) for AXS-05 for the treatment of major depressive disorder. The Company is reviewing the proposed labeling and will respond to the FDA for final labeling approval.”

The filing sparked a frenzy among investors – most of whom have had a steady diet of bad biotech news to digest this year – sending shares of Axsome $AXSM soaring 51% after the bell and pushing its market capitalization to 1, $44 billion.

It’s a polar shift from last summer, when Axsome announced that the process of labeling their potential blockbuster for the Major Depressive Order had been shelved after regulators identified “gaps” that had interrupted discussions on the label.

There’s no guarantee of success, of course, but regulators and developers typically hash out a drug label in the weeks leading up to an approval. So the long-delayed drug now has a chance for short-term success.

Axsome got the party started again for AXS-05 in April when an earlier filing with the SEC indicated that they had reached an agreement with the FDA on post-marketing terms.

Axsome’s drug offers a combination of dextromethorphan and bupropion, which some analysts enthusiastically believe can fetch more than $1 billion a year. And biotechnology has won breakthrough titles at the FDA for major depression as well as Alzheimer’s disease agitation as Lundbeck now makes strides.

Marc Goodman of SVB Securities picked up on the matter in a note, saying:

The usual process is that the FDA and a company would start labeling negotiations about a month before the PDUFA date, but since there is no action date, it’s hard to know when. in this situation, but we will assume approval in about 1 month. Given the saga of this drug approval process, we think many investors are still somewhat hesitant about full approval, and so we wouldn’t be surprised to see another significant jump in the stock on approval. complete.

Axsome has also been battling issues around its migraine drug AXS-07, which was rejected a few weeks ago over CMC issues.

Help for those struggling with chronic fatigue syndrome Mon, 27 Jun 2022 01:00:00 +0000

BATON ROUGE, La. (BRPROUD) – When someone who has been diagnosed with the flu, COVID or a similar illness says they are too tired to do anything but rest, it is generally considered understandable .

But a condition that affects an estimated 836,000 to 2.5 million Americans and has a similar tiring effect is often dismissed and not taken seriously by the general public.

Many who suffer from chronic fatigue syndrome say acquaintances, employers and even family members have accused them of being “lazy” or “flaky,” instead of empathizing with their related struggle. to health.

One patient said: “The disease was seen by my employer mainly as a simple inability to cope with stress.”

Another lamented: “Although it is recognized/listed as a neurological disease by the World Health Organization and the Ministry of Health, my sad experience has been that help for people with this disease is scarce and spaced out. Patients like me and their caregivers still face disbelief and stigma from some members of the medical profession and, in some cases, incredibly poor, inappropriate and inexcusable treatment.

So what exactly is chronic fatigue? And, is there a treatment for it?

Defining chronic fatigue Syndrome

The cause of chronic fatigue syndrome (CFS) is not yet clear, but its symptoms are well defined.

CFS is commonly known as a condition that causes deep exhaustion, trouble sleeping, pain, dizziness, memory problems, and other symptoms that are made worse by exertion.

Experts say its main symptom is a relentless, unrelenting feeling of fatigue that lasts more than six months and does not improve with rest.


Although there is currently no cure for CFS, doctors often recommend therapies that focus on symptom relief.

According to the Mayo Clinic, these therapies may include:

Drugs that treat:

The Depression Many people with long-term health conditions, such as chronic fatigue syndrome, are also depressed. Treating your depression can help you cope with the problems associated with chronic fatigue syndrome. Low doses of certain antidepressants can also help improve sleep and relieve pain.

Orthostatic intolerance- Some people with chronic fatigue syndrome, especially teenagers, feel weak or nauseous when standing or sitting. Medicines to regulate blood pressure or heart rate may be helpful.

Pain- If over-the-counter medications such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve) don’t help enough, prescription medications sometimes used to treat fibromyalgia might be options for you. These include pregabalin (Lyrica), duloxetine (Cymbalta), amitriptyline, or gabapentin (Neurontin).

Other therapies that treat:

Tips- Talking with a counselor can help develop coping skills to cope with chronic illness, overcome limitations at work or school, and improve family dynamics. It can also be helpful in managing depression.

Sleep problems- Sleep deprivation can make other symptoms more difficult to manage. Your doctor might suggest avoiding caffeine or changing your bedtime routine. Sleep apnea can be treated using a machine that delivers air pressure through a mask while you sleep.

Fitness Routines- Aggressive exercise programs often lead to worsening of symptoms, but maintaining tolerated activities is important to prevent deconditioning. Exercise regimens that start at a very low intensity and increase very gradually over time can be helpful in improving long-term function.

Although experts have a lot to learn about the root cause of CFS, some patients battling the disease report feeling some relief by sticking to a healthy diet, sleeping regularly, exercising regularly (if possible) and staying hydrated.

An empathetic group of friends and family members can also be helpful in reminding the victim to be patient with themselves and not push themselves too hard.

Local help for people with CFS

Click here to view a list of Baton Rouge-based doctors who specialize in helping patients with CFS.

Lighthouse Network helps people find the best Christian depression treatment centers in the United States Thu, 23 Jun 2022 02:01:46 +0000

Lighthouse Network offers online life growth resources and 24/7 helplines. Over the years, they have helped people find joy, peace, and freedom. to reach their God-given potential. The department is always ready to guide callers through their processes and services to ensure they feel comfortable. They have caring, experienced and expert professionals who help them get the proper treatment they need. Thus, individuals can be assured of getting exceptional solutions from the department.

Speaking of the ministry’s passion for counseling, the society’s spokesperson said, “The BIBLE is the most accurate representation of our minds and the world. It is also the best instruction book for everyday life. At Lighthouse Network, we want various healing programs to provide as much psychological, spiritual, and biological depth as possible, and then weave these three spheres together. We are aware that each treatment program can improve each of the spheres and can interweave them. Our passion is to transform lives and heal hearts.

In the modern world, many individuals seem to have everything anyone could want. However, they feel miserable and inconsolable. If their misery is not addressed, these people may contemplate or even commit suicide. Mental health is essential and should not be taken for granted. Lighthouse Network helps callers get the mental health treatment they need. The ministry connects the one to the best mental health treatment facilities in the USA.

Speaking about the department’s services, the company spokesperson said: “When individuals struggle with mental health issues or addiction issues, they typically find it difficult to navigate the complicated healthcare system to get treatment. This is why we are committed to guiding these people through the health system. Our ministry ensures that everyone has access to exceptional services and treatment programs.

Looking for best christian depression treatment centers? Lighthouse Network is an organization aware that many people around the world struggle to deal with various emotions such as anxiety, depression, anger and many more. That’s why, they are committed to connecting people with Christian and religious treatment for depression, addiction, and anxiety. With the ministry, one can be assured of getting treatment that improves one’s relationship with oneself, one’s loved ones, and God. The ministry offers hope to people struggling with mental health issues.

About the Lighthouse Network

Flagship Network offers many outpatient and residential treatment options in the United States. They pride themselves on providing the best Christian mental health helplines in the country. The ministry deals with issues related to depression, drug addiction, alcohol and many more. They help people find their way back to life and wholeness.

Contact details

Flagship Network

PO Box 57,

Greenville, Florida 32331

Phone: 844-LifeChange (543-3242)


Media Contact
Company Name: Flagship Network
E-mail: Send an email
Call: (844) 543-3242
Address:PO Box 57
Town: Greenville
State: FL 32331
Country: United States

Now the “party drug” ketamine will work as a quick antidepressant? American researchers tell us how Tue, 21 Jun 2022 06:01:33 +0000

Bengaluru: Previous studies have shown that ketamine is a rapid antidepressant, acting in just hours to produce a substantial alteration in a patient’s state of mind, unlike traditional antidepressants which can take several weeks to show results.

Now, to understand the molecular mechanism of how the drug works so quickly, a team of researchers from Chicago, USA observed neural activity in the brains of mice exposed to ketamine.

The results of the study, which were peer-reviewed, have been published in the scientific journal Nature Communication last month.

Ketamine is an anesthetic, primarily used to induce strong pain relief and sedation. It is commonly used as a surgical anesthetic for animals. It has also been used recreationally since its inception in various forms and can be addictive when used frequently.

A single dose of ketamine can decrease depressive symptoms within hours and its effects on the brain can persist for up to three weeks. Previous studies show that even patients resistant to antidepressants respond to even a single dose of ketamine.

Traditional antidepressants work through neurogenesis, or the creation of new neurons, while ketamine, according to the Chicago scientists, appears to work like other psychedelics – illuminating existing pathways in the brain that were previously turned off, indicating depression. This effect was observed within hours by researchers when cells were activated by ketamine in mouse models.

The authors of the Nature study noted that ketamine treatment activated neurons in the hippocampus – the region of the brain associated primarily with memory and learning stressed and unstressed mice.

However, since ketamine can have significant and serious side effects – blurred vision, nausea, insomnia, drowsiness and addiction – it can only be used for a limited time.

For the study, the scientists genetically modified the test mice so that they could switch on and off the activity of newly born neurons in adult mice, also called adult-born immature granule neurons (ABIN).

Ketamine treatment activated ABINs in stressed and unstressed mice. And, they found that blocking ABIN activity also blocked the antidepressant effects of ketamine.

Thus, the researchers were able to reduce the change in neuronal activity without any change in the number of neurons, stating that “the increased activity of ABINs is sufficient for rapid antidepressant effects”.

Although the beneficial effects of ketamine do not appear to last as long as those of some psychedelics, the latest findings have offered a deeper window into how these drugs work, as the study identified a specific cell population that can potentially be targeted to limit the negative effects. of ketamine while preserving therapeutics and benefits.

Ketamine to treat addiction

Increasingly, research has shown that certain substances, classified as “gateway drugs,” such as psychedelics (psilocybin in mushrooms, ayahuasca, LSD), help reverse depression. They, too, work by activating previously existing neural connections that had been turned off in brain regions associated with depressive disorder.

Ketamine has also shown promise in the treatment of addiction. When combined with therapy, the drug has been shown to help rewire the brains of alcohol addicts and reverse their addiction.

Neurons are normally produced continuously in the brain and the process of neurogenesis takes weeks to complete. As a result, standard depression treatments also take weeks to see small results.

But studies have indicated that substances that haven’t been well studied and have been classified as illegal drugs can actually act instantly like antidepressants, often retaining rewired neural connections for weeks or even months.

(Editing by Zinnia Ray Chaudhuri)

Read also : Psychedelic drugs may be the answer to depression and so much more

]]> The best online therapy for anxiety in 2022 Fri, 17 Jun 2022 21:33:46 +0000


  • Accepts multiple insurance plans
  • Medications available through Talkspace Psychiatry
  • Individual, couple and teen consultations available

The inconvenients:

  • Must pay extra for live video sessions
  • Can be expensive if you are only looking for a few sessions

Session Types Text, video and voice messaging; live video

Cost and payment options Prices vary and are dependent on geographic location, but typically start at $79 per week for Messaging Therapy, $109 per week for Live Therapy, and $139 per week for Live Therapy Plus Messaging Combination, with plans billed monthly; Talkspace Psychiatry is $249 for the first session and $125 for follow-up sessions

Prescribes medication Yes, via Talkspace Psychiatry

Accept insurance Yes

If you’re looking for a comprehensive online counseling platform that offers mental health and psychiatric services to individuals, couples, and teens aged 13-17 living with anxiety, then Talkspace may be worth a look. considered.

Talkspace has licensed therapists and counselors who have expertise in areas such as anxiety, obsessive-compulsive disorder (OCD), phobias, mood disorders, and more. Because they require providers to have at least a master’s degree and a minimum of 3,000 hours of clinical experience, you’ll have access to highly trained mental health experts.

The platform also hosts Talkspace Psychiatry, which provides online psychiatric services and adult medication management. This feature sets Talkspace apart from its competitors who do not prescribe medication. This can get expensive if you need both medication management as part of the psychiatric plan and counseling as part of the therapy plan. However, this approach may be beneficial for people with anxiety, as anxiety symptoms often respond well to a combination of psychotherapy and medication, according to a meta-analysis of studies published in .

Talkspace is one of the few online anxiety therapy platforms that accepts insurance, which can help you manage your costs. According to our assessment team’s April 2022 survey of 1,000 online therapy users, nearly 39% said they chose a platform primarily because it accepted their insurance.

Talkspace offers several options for meeting with a therapist, including “messaging only” and “messaging + live session” subscription plans. This is an important detail to pay attention to when choosing an online therapy platform for anxiety. A messaging-only plan means there are no live video or phone sessions with a therapist. Instead, patients only have access to their therapist through messaging in the virtual therapy room. This option isn’t conducive to immediate feedback, as you have to wait for the therapist’s response, although they promise to respond five days a week, according to an email we received from a customer service representative. You can upgrade to other plans that include video and audio messaging, although that also increases the cost.

Unlike other platforms that are upfront and transparent about pricing, Talkspace asks you to fill out an intake questionnaire to get the exact price of its packages. This can be frustrating if you’re in the research phase and just want to quickly scan each site. However, we have put together some general pricing information to help you get a better idea of ​​how much their programs cost:

  • Messaging Therapy Text, video and audio messaging; from $69 per week or $276 per month
  • Live therapy Four 45-minute live therapy sessions per month; from $99 per week or $396 per month
  • Live messaging therapy plus Text, video and audio messaging; four 45-minute live sessions per month; from $129 per week or $516 per month
  • Therapy for adolescents (13 to 17 years old) Text, audio and video messaging only (no live sessions); $260 per month
  • Psychiatrist sessions $249 for the first consultation and $125 for any follow-up visit

Although the website’s homepage mentions that it has over 60,000 five-star reviews, Talkspace has a customer review rating of just 1.09 stars out of 5 on BBB and 1.3 stars out of 5 on Trustpilot. . Common complaints include billing issues and poor customer service.

A new oral treatment will soon be available for postpartum depression Thu, 16 Jun 2022 00:58:11 +0000

New mothers will soon have access to oral treatment for postpartum depression.

Postpartum depression affects nearly 1 in 7 women who give birth in Australia each year. While it’s safe to say that every parent will go through a period of adjustment as they care for a newborn and navigate the challenges that come with a new baby in the household, for some this period can lead to feelings of depression. Despite the fact that postpartum depression is especially common in new mothers, medications are limited when it comes to treatment. Fortunately, all of that could be about to change as a drug to treat postpartum depression may soon be available orally, dramatically improving access for patients.

Thanks to the work of Monash University researchers in partnership with PureTech Health plc, an oral form of allopregnanolone has been created, with the pill having the potential to dramatically increase convenience and user-friendliness when it comes to treating depression postpartum. Currently, allopregnanolone is the only FDA-approved drug on the market, but it must be given as a 60-hour intravenous infusion to ensure it is broken down in the liver.

With the new development of this oral treatment, the drug is absorbed into the lymphatic system and directed away from the liver through the lipid absorption pathways of the human body. As Women’s program reports, “Professor Chris Porter and his team at the Monash Institute of Pharmaceutical Sciences developed the new drug delivery technology, ‘Glyph’, which showed that when the drug was delivered through the platform, the rates Systemic blood levels were approximately nine times greater than those of orally administered allopregnanolone, based on previous data.

The development is particularly groundbreaking and marks the first clinical validation of Glyph technology in humans. Speaking of the medical milestone, Professor Porter said: “These data show that allopregnanolone can be successfully administered orally, which is very encouraging not only for women with PPD, but also for those suffering from other neurological and neuropsychiatric conditions, including other forms of depression. , anxiety and sleep disturbances, who could benefit from an oral form of allopregnanolone.

“Because Glyph redirects drug transport through the lymphatic system, it has the potential to improve the bioavailability of orally administered drugs like allopregnanolone. Since it selectively transports therapeutic agents into the lymphatic system, it has the potential to target therapies at the immune system. We hope that LYT-300 will be the first of many applications for Glyph.

Scientists will now investigate how the substance can best be administered by exploring the dose and the effect of food on oral absorption as well. The next step in LYT-300’s multi-part program will be its evaluation of safety and tolerability over a range of doses, before then hopefully identifying a dose to move forward.

Australian tech in postnatal depression pill breakthrough Tue, 14 Jun 2022 06:00:00 +0000

Researchers at Monash University hope a technology they have invented will allow women who must undergo lengthy intravenous infusion treatments for postnatal depression to take a simple pill instead.

Monash has worked with Nasdaq-listed biotech PureTech Health to research whether its drug delivery platform, called Glyph, will mean that a drug registered in the United States to treat postnatal depression can be delivered as a oral capsule instead of an IV infusion.

The university’s drug delivery platform is being tested as a way to deliver postpartum depression medication via a pill instead of an IV. Credit:Shutterstock

The drug called allopregnanolone is licensed in the United States for postnatal depression, but can only be given by intravenous infusion over 60 hours. Like many other drugs, the product cannot be taken orally because the liver breaks it down to such an extent that it is not sufficiently absorbed by the body.

“The liver breaks it down and none of it makes it into the general circulation,” said Monash Institute of Pharmaceutical Sciences director Professor Chris Porter.

There are a number of other medications that also require IV injections. These treatments are time-consuming and require patients to spend hours in hospitals or day clinics, so researchers are looking for alternatives.

Porter and his team have been working for years on the Glyph System, which aims to solve this problem by coaxing drugs to absorb through the lymphatic system, the network of vessels and nodes that transport excess fluid into the body. When drugs travel through this route, they bypass the liver.

“If you can persuade drugs to use the lymphatic system, well that way [and] the plumbing bypasses the liver completely,” Porter said.

Early data from a Phase 1 study for the treatment of depression showed that patients who received a pill using Monash’s technology saw a significant increase in blood levels of the drug compared to previous attempts to give the drug by mouth rather than by injection.

This suggests that the drug could one day be taken in pill form, rather than long infusions, which is difficult for patients suffering from depressive episodes.

A ‘tidal wave’ in psychology: Advocates call on lawmakers to approve psilocybin treatment Sun, 12 Jun 2022 10:43:34 +0000

Mark Keller still uses his “Slider” call sign, even though he retired from the Navy in 2012.

Keller excelled in his 20 years as a naval flight officer. But when he retired, the trauma of an incident in 2005, when he accidentally killed 12 innocent people, began to resurface, he said.

Like many veterans, Keller has? Post-traumatic stress disorder. He sought help first from the US Department of Veterans Affairs, which he called “incompetent”, and then from private healthcare providers, who prescribed him Ativan, a sedative.

Ativan, Keller said, was “not the right answer”; he became addicted.

“I lost my family. I lost my business. I was once homeless at one point,” Keller said. “And I was a drug addict.”

And, says Keller, it wasn’t healing. While coming out of his addiction, he said he heard from a friend about veterans who received psilocybin treatment for PTSD in Peru. Keller traveled to Peru and received the treatment himself, which he described as “profound”.

“I found a peace that I had never known before,” Keller said. “I felt the love of God.”

Keller got involved with No Fallen Heroes, a documentary that advocates psychedelic treatment for veterans. He shared his story Wednesday at a Capitol press conference hosted by the Center for Psychedelic Education and reason to hopewho advocate for access to psychedelic therapy.

“Why do we go away and fight these wars for our country,” Keller asked, “and come back with these wounds, and there’s nothing for us?”

Can magic mushrooms help fight mental illness? A bipartisan group of Pennsylvania lawmakers think so.

Rep. Tracy Pennycuick, R-Montgomery, asked the same question. With his bill to start psilocybin trials, a drug found in “magic mushrooms” that has psychedelic effects, she hopes to make Pennsylvania the latest state to increase access to psychedelic mental health treatments. But it is unclear whether the bill will pass.

Psilocybin is one of many psychedelic mental health treatments, including ketamine and MDMA, that researchers have recently discovered to have potential as mental health treatments. Studies suggest that psilocybin may be able to treat depression, PTSD, anxiety, obsessive-compulsive disorder, and substance use disorder, among others.

Pennycuick is a veteran and has suffered from PTSD since 2012 due to a traumatic experience when she was an Army helicopter pilot. She introduced the bill because she was frustrated with the lack of progress in PTSD treatments and saw promise in psilocybin.

“Right now, veterans with PTSD have a mirage of opportunity. Yoga, service dogs, warrior writing, warrior photography,” Pennycuick said. because we are losing 20 veterans a day.”

But Pennycuick’s bill has been sitting on the House Health Committee since 2021.]He can’t walk out of the committee until the committee chair, Rep. Kathy Rapp, R-Warren, clears it. And in March, Rapp seemed to disagree with the bill.

Pennycuick’s invoice, if successful, would create clinical trials for psilocybin treatment. This treatment would give priority to veterans and retired first responders and their family members.

Bills legalizing psilocybin therapy through trials and research have become quite common in state legislatures. The bill in the House would look like the one that recently spent in Connecticutwhich the Center for Psychedelic Education also supported. Texas passed a law create psychedelic medicine studies for veterans last year.

The Maryland legislature passed a bill funding psilocybin treatment for veterans, but the governor has yet to pass it. Oklahoma The House of Representatives has passed a bill for psilocybin research, but it is still awaiting a vote in the Senate.

Oregon legalized psilocybin by referendum in 2020 and the program will be implemented in 2023.

However, it is more common for psilocybin bills to gain momentum but not make it out of the legislature, such as in Pennsylvania. It happened in Washington and Maineamong other states.

Sometimes bills to legalize medical psilocybin would also decriminalize it for recreational use. New Hampshire, Rhode Island, and Missouri have bills in their legislatures to that effect; The New Hampshire bill passed the House but stalled in the Senate, and the rest of the bills are stalled in committee.

Finally, some states are not yet ready to legalize psilocybin, but have passed – or are in the process of passing – legislation to explore whether or how they should legalize it. This is the case in Hawaii, Utah, Washingtonand Georgia.

The Center for Psychedelic Education said it would advocate for bills like Pennycuick’s in other states, including Florida.

Jesse Gould, a veteran who said psilocybin “saved [his] life,” said the treatment would be a “tidal wave” through psychology.

“You can see history in the making and you have a choice which side of history you want to stand on. And so you can either make the hard choice and support veterans right now,” Gould said, “ or you can wait five years when it’s easy, and everyone’s already on that vote, and your choice doesn’t really have that effect.”

“We always hear politicians say, ‘Hey, I support veterans,'” Gould said. “Now is your chance to show it. And psychedelic modalities are the best way for you to support the troops.